Endocrine Abstracts

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of hypertension concerning about 5–12% of hypertensive individuals. Aldosterone to renin ratio (ARR) and 24 h urine aldosterone concentration (24-UAC) are important tools in PHA screening diagnostics. The most appropriate cutt off values predicting PHA are still being discussed. The study is to assess siutability and to determine optimal cut off values of ARR and 24-UAC for accurate PHA pred...

Introduction: Generously supported by IPSEN)-->Acromegaly is associated with increased morbidity and mortality, mainly due to cardiovascular and metabolic complications and higher risk of malignancy. The treatment of choice is selective transsphenoidal surgery (TSS). Successful removal of somatotroph adenoma normalizes GH and IGF1 levels, which improves the patients prognosis. The efficacy of TSS depends on the tumor volume, parasell...

Introduction: Subclinical hyperthyroidism (SH) affects about 1% of population. The diagnosis of this disease leans on the laboratory criteria only: decreased of TSH and normal FT3 and FT4 levels. SH increases mortality mostly due to cardiovascular diseases including arrhythmia and overload of the heart. Enlarging of heart chambers is one of the cause of arrhythmia, and cardiac index is one of indicators of heart after load.Aim: To e...

Introduction: Lack of radioiodine uptake in differentiated thyroid carcinoma (DTC) is a big diagnostic and therapeutic problem. This sign is associated with worse prognosis. In NRADTC patients with elevated thyreoglobulin levels with no evidence of disease in radioiodine scintigraphy, scintigraphy with the somatostatin analog labeled with 99mTc seems to be an alternative imaging method.Aim: Assessment of scintigraphy with the somatostatin anal...

Background: Hypercortisolism in Cushing’s disease (CD) is associated with high cardiovascular risk. Hemodynamic disturbances, especially excessive vasoconstriction and elevated blood pressure (BP), may contribute to accelerated myocardial remodeling. Early identification of subclinical left ventricular (LV) dysfunction may be crucial for optimizing treatment and reducing mortality in patients with CD.Purpose: The aim of this study was to assess the ...

Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and...

Mutations in the (glucokinase) GCK gene are, along with the HNF1A gene mutations, the most frequent cause of (maturity onset diabetes of the young) MODY. Heterozygous loss-of-function GCK mutations result in a moderate fasting hyperglycemia. The GCK-MODY patients are usually free from microvascular complications; however, little is known about atherosclerosis and intermediate related phenotypes. We aimed to examine intima-media thickness (IMT) and endothelial function in GCK-M...

Background: The influence of hyperinsulinemia and insulin resistance on thyroid function is debatable. Insulin, as an anabolic hormone, may also play a role in thyroid hypertrophy and nodular goitre development. Some recent reports focus on the possible interplay between thyroid function and glucose status in pregnancy, including gestational diabetes mellitus.Aim: The study aimed to assess the relationship between insulin resistance indices and thyroid f...

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...

Acromegaly is caused by growth hormone-secreting adenoma in more then 95% cases. Ectopic secretion of GH-RH is a rare cause of acromegaly accounting for less than 1% of all cases. The most frequent source of ectopic GHRH is bronchial carcinoid. Clinical and biochemical findings are similar in both conditions. A distinction of pituitary vs extrapituitary acromegaly is important in planning effective management and both reasons should be considered in the diagnostic process....